Ep. 67: Endotoxin and PUFA As Primary Causes of Fatty Liver Disease (NAFLD Part 5)

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In this episode we discuss:

  • How endotoxin drives inflammation and stress while downregulating our metabolism 
  • Why alcoholic fatty liver disease isn’t all that different from non-alcoholic fatty liver disease
  • The protective effects of saturated fats in NAFLD 
  • How endotoxin and polyunsaturated fats can cause NAFLD 
  • Nutrient deficiencies that contribute to energy failure and NAFLD

3:57 – the role of endotoxin in NAFLD 

23:43 – how endotoxin drives inflammation and stress while downregulating our metabolism

30:35 – research looking at endotoxin as the cause of NAFLD 

38:30 – how endotoxin mediates alcoholic liver disease and the protective effects of saturated fats 

44:56 – endotoxin and other damaging factors in the larger context of NAFLD 

52:52 – the role of PUFA in NAFLD 

1:12:05 – the contrasting effects of saturated fats and PUFA in alcohol-induced liver damage 

1:24:22 – how nutrient deficiencies can cause energy failure and drive NAFLD 

1:34:57 – how alcohol causes fatty liver and why alcoholic liver disease doesn’t vary considerably from NAFLD 

1:38:49 – other factors that contribute to energy failure and drive NAFLD, including psychological stress, fasting, low-carb diets, low-calorie diets, excessive exercise 

Links from this episode

  • Endotoxin inhibits mitochondrial respiration (12) 
  • Endotoxin absorbed with saturated fat does not cause the inflammation or symptoms that would be expected (123)

  • Nitric oxide inhibits efficient mitochondrial respiration (12345678) 

  • The role of endotoxin in NAFLD (12, 3, 4)
  • Endotoxin causes intestinal permeability (12) 

  • Endotoxin mediates alcoholic fatty liver disease (1, 2, 3, 4, 5, 6)
  • Saturated fats and cholesterol protect against and reverse alcohol-induced liver damage while unsaturated fats exacerbate the damage (1234567, 8) 
  • Ep. 9: Polyunsaturated Fats (PUFA) and Energy Balance (podcast episode)
  • Fats: We’ve Got It All Wrong (article)
  • Omega-3s Are NOT The “Healthy Fats” (article)
  • The role of PUFA metabolites/oxidation in NAFLD (1, 2, 3, 4, 5, 6)
  • Alcohol directly contributes to the energy failure that causes NAFLD, and this effect is reversed by fructose. (1, 2, 3)
  • Testosterone and vitamin E improves NAFLD in humans (1)
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